The Runx (runt-related protein) family of transcription factors plays important roles in different tissues and cell lineages. Runx1 determines commitment to the hematopoietic cell lineage and Runx2 determines commitment to the osteoblastic lineage. Cbfbeta is required for Runx1- and Runx2-dependent
The Foxa family of transcription factors in development and metabolism
β Scribed by J. R. Friedman; K. H. Kaestner
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 200 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1420-682X
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Gene targeting has allowed the dissection of complex biological processes at the genetic level. Our understanding of the nuances of skeletal muscle development has been greatly increased by the analysis of mice carrying targeted null mutations in the Myf-5, My00 and myogenin genes, encoding members