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The MyoD family of transcription factors and skeletal myogenesis

✍ Scribed by Michael A. Rudnicki; Rudolf Jaenisch

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
853 KB
Volume
17
Category
Article
ISSN
0265-9247

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✦ Synopsis

Gene targeting has allowed the dissection of complex biological processes at the genetic level. Our understanding of the nuances of skeletal muscle development has been greatly increased by the analysis of mice carrying targeted null mutations in the Myf-5, My00 and myogenin genes, encoding members of the myogenic regulatory factor (MRF) family. These experiments have elucidated the hierarchical relationships existing between the MRFs, and established that functional redundancy is a feature of the MRF regulatory network. Either MyoD or Myf-5 is sufficient for the formation or survival of skeletal myoblasts. Myogenin acts later in development and plays an Accepted essential in vivo role in the terminal differentiation of myotubes.

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