The structure of the chromophore chromomyclnone was deduced as Indicated in the following scheme. Chromomrcin A3 1 CH3COOH, boil 2 hrs Chromomvcinone (CHR) UV same as chromomycin A5 :. Chromophore still intact. Chromomycinone No.34 m.p. 183-135', having a typical naphthoquinone UV spectrum, A",izH 2
The four chromoses from chromomycin A3
β Scribed by M. Miyamoto; Y. Kawamatsu; M. Shinohara; K. Nakanishi; Y. Nakadaira; N.S. Bhacca
- Publisher
- Elsevier Science
- Year
- 1964
- Tongue
- French
- Weight
- 292 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Chromomycin is the name given to a group of cancerostatic antibiotics produced by Strentomyces griseus No.?, and is a mixture of several closely related compounds 1) . The principal
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## Abstract Binding of chromomycin A~3~ (CRA) to calf thymas DNA was investigated in the presence of divalent cations using visible absorption and ^1^Hβnmr spectroscopies. An apparent equilibrium binding constant (βΌ 10^11^__M__^β1^) was obtained from metal competition experiments using EDTA to remo
## Abstract Three structurally related anticancer drugs, mithramycin, chromomycin A~3~, and olivomycin, showed large unexpected differences (up to more than 1000 fold) in their toxicity towards cultured cells from various species (human, Chinese hamster, Syrian hamster, and mouse). Among the cell t
The chromomycins are a group of cancerostatic antibiotics produced by Streptomyces griseus 1) and are undoubtedly closely related to olivomycin 2) and several other antibiotics 3, isolated by various groups. 4) The principal constituent, chromomycin A3@) is commercially available , while chromomyci
The interactions of the antitumor antibiotics, chromomycin A,, with a variety of metal cations in the pH range of 3.0-8.5 were systematically studied by CD, absorption, and 'H-nmr spectroscopies. Results were compared with thaw obtained in the presence of increasing amounts of calf thymus DNA. The n
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