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The formation and functioning of yeast mitotic spindles

✍ Scribed by Hirohisa Masuda

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
860 KB
Volume
17
Category
Article
ISSN
0265-9247

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✦ Synopsis

The mitotic spindle contains the machinery responsible for sister chromatid segregation. It is composed of a complex and dynamic array of microtubules, which are nucleated from the spindle poles. Studies of yeast spindle functions by molecular genetic analysis and by in vitro functional analysis have identified proteins that are mitosis-specific and present at very low concentrations in the cell, and have revealed the molecular bases of several processes required for the formation and functioning of the mitotic spindle.

Here I review the current knowledge of the processes that are common to most eukaryotes: microtubule nucleation at the spindle poles, bipolar spindle assembly, maintenance of the spindle structure, chromosome attachment to

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