✦ LIBER ✦

Dr. Dolittle and the making of the mitotic spindle

✍ Scribed by Margarete M. S. Heck

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 211 KB
Volume: 21
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199912)22:1<985::aid-bies2>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

The intrinsic polarity of microtubules within cells is exploited each time cells divide. Kinesins, microtubule-associated motor proteins, are required to execute the dramatic events of mitosis: bipolar spindle assembly, metaphase chromosome alignment, anaphase chromosome segregation, and separation of spindle poles prior to cytokinesis. Surprisingly, kinesin-related proteins have been found to move in either ''plus-ward'' or ''minus-ward'' directions along microtubules. Evidence from genetic analyses of simple eukaryotes and in vitro activity assays supports the notion that certain subfamilies of kinesin-related proteins provide antagonistic activities necessary to balance mitotic forces. A recent study by Sharp et al. sheds further light on the subject by exploiting the genetics and cytology of the fruit fly embryo.

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