The formation and analysis of n-nitrosamines
β Scribed by James K. Foreman; Kenneth Goodhead
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 863 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-5142
No coin nor oath required. For personal study only.
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Dimethylnitrosamine, nitrosomorpholine, nitrosopyrrolidine, nitrosopiperidine, nitrosoazetidine, hexamethylenenitrosamine, nitrosornethylcyclohexylamine, nitrosomethylaniline and dinitrosopiperazine have been prepared labeled with tritium by nifrosation of the corresponding amines which had been lab
A number of important reactions involved in the formation and metabolism of N-nitrosamines have been studied using a modified reaction field method which treats the solute quantum mechanically and the solvent as a polarized dielectric.
The geometry of a proposed intermediate (a-dialkylamino nitrite ester) of N-nitrosamine synthesis from nitrites is studied by ab initio SCF methods. The energy of a zwitterion is calculated and found to be high.
## Abstract Phenolic compounds which can potentially form Cβnitroso derivatives by reaction with nitrite can act as catalysts on the formation of an __N__βnitrosamine from nitrite and a secondary amine. Using a gas chromatographic technique, this effect has been measured for diβ and trihydric pheno