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The Folic Acid Activity and Antagonism of Two Structurally Related Derivatives of Benzimidazole

โœ Scribed by EDWARDS, P. C.; STARLING, D.; MATTOCKS, A. M.; SKIPPER, H. E.


Book ID
121141589
Publisher
American Association for the Advancement of Science
Year
1948
Tongue
English
Weight
141 KB
Volume
107
Category
Article
ISSN
0036-8075

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The immunosuppressive structure-activity relationships of substituted cinchoninic acid derivatives related to Brequinar were explored. Activities as inhibitors of dibydroorotate dehydrogenase and the mixed lymphocyte reaction were related to benzo-ring substitution, replacement of the benzo-ring by