The folding and design of repeat proteins: reaching a consensus
β Scribed by Ewan RG Main; Sophie E Jackson; Lynne Regan
- Book ID
- 114314645
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 404 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0959-440X
No coin nor oath required. For personal study only.
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**The cover picture shows** an illustration of consensus design, a powerful proteinβengineering method that is based on sequence alignments of homologous proteins. An alignment of ankyrin repeats is shown in the sequence plane, and a consensusβdesigned ankyrin repeat protein based on this alignment
## Abstract Repeat proteins comprise tandem arrays of a small structural motif. Their structure is defined and stabilized by interactions between residues that are close in the primary sequence. Several studies have investigated whether their structural modularity translates into modular thermodyna