A recurring theme in protein engineering: the design, stability and folding of repeat proteins
β Scribed by Ewan RG Main; Alan R Lowe; Simon GJ Mochrie; Sophie E Jackson; Lynne Regan
- Book ID
- 113883001
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 408 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0959-440X
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π SIMILAR VOLUMES
## Abstract Repeat proteins comprise tandem arrays of a small structural motif. Their structure is defined and stabilized by interactions between residues that are close in the primary sequence. Several studies have investigated whether their structural modularity translates into modular thermodyna
The solution to the protein folding problem lies in defining the relative energetic contributions of short-range and long-range interactions. In other words, the tendency of a stretch of amino acids to adopt a final secondary structural fold is context dependent. Our approach to this problem is to a