The first use of chiral oxazoline ligands in the highly enantioselective diethylzinc addition to diphenylphosphinoyl imines

✍ Scribed by Xiaomei Zhang; Wenqing Lin; Liuzhu Gong; Aiqiao Mi; Xin Cui; Yaozhong Jiang; Michael C.K Choi; Albert S.C Chan

• Book ID: 104250441
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 62 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00014-x

✦ Synopsis

A series of chiral oxazolines, which had been conveniently prepared from commercially available (1S,2S)-2-amino-1phenylpropane-1,3-diol, was applied in the diethylzinc addition to diphenylphosphinoyl imines to give high yields of 68-84% and excellent e.e. values of 90-93%.