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The first synthesis of optically active 1-substituted taurines

โœ Scribed by Jiaxi Xu; Shu Xu; Qihan Zhang


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
88 KB
Volume
16
Category
Article
ISSN
1042-7163

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โœฆ Synopsis


Optically active 1-substituted taurines, a type of important sulfur analogues of naturally occurring amino acids, and their N-benzyloxycarbonyl-protected derivatives were synthesized from the corresponding optically active ฮฒ-amino secondary alcohols in three steps via N-protection with benzyl chloroformate, substitution with thiolacetic acid under Mitsunobu conditions, and oxidation with performic acid.


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