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The first synthesis of optically active 1-substituted taurines
โ Scribed by Jiaxi Xu; Shu Xu; Qihan Zhang
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 88 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1042-7163
- DOI
- 10.1002/hc.20133
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โฆ Synopsis
Optically active 1-substituted taurines, a type of important sulfur analogues of naturally occurring amino acids, and their N-benzyloxycarbonyl-protected derivatives were synthesized from the corresponding optically active ฮฒ-amino secondary alcohols in three steps via N-protection with benzyl chloroformate, substitution with thiolacetic acid under Mitsunobu conditions, and oxidation with performic acid.
๐ SIMILAR VOLUMES
Simple optically active selenoxides (5-11 $e.e.) were prepared resolution procedure and were demonstrated to be configurationally unstable as catalyzed achiral hydrate formation.