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The first synthesis of chiral PNA monomer-cyclen conjugates

โœ Scribed by Li-Jian Ma; Guo-Lin Zhang; Shan-Yong Chen; Bo Wu; Jing-Song You; Chuan-Qin Xia; Xiao-Qi Yu


Book ID
105360503
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
131 KB
Volume
11
Category
Article
ISSN
1075-2617

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Synthesis of the first chiral PNA monome
โœ Stefano Maiorana; Emanuela Licandro; Dario Perdicchia; Clara Baldoli; Barbara Va ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 239 KB

The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO) 4 moiety represents a suitable spectroscopic probe for diagnostic