Synthesis of the first chiral PNA monome
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Stefano Maiorana; Emanuela Licandro; Dario Perdicchia; Clara Baldoli; Barbara Va
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Article
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2003
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Elsevier Science
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English
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The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO) 4 moiety represents a suitable spectroscopic probe for diagnostic