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The first recurring chromosome translocation in hepatoblastoma: Der(4)t(1;4)(q12;q34)

✍ Scribed by Nancy R. Schneider; Linda D. Cooley; Milton J. Finegold; Edwin C. Douglass; Gail E. Tomlinson

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 77 KB
Volume: 19
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199708)19:4<291::aid-gcc13>3.0.co;2-j

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✦ Synopsis

We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q12;q34), whereas the fourth case appeared to have a der(4)t (q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene or genes on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin.

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