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The first example of a regioselective Biginelli-like reaction based on 3-alkylthio-5-amino-1,2,4-triazole

✍ Scribed by Qiong Chen; Li-Li Jiang; Chao-Nan Chen; Guang-Fu Yang

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 227 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.1

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✦ Synopsis

Abstract

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The three‐component condensation of 3‐amino‐5‐alkylthio‐1,2,4‐triazoles with aromatic aldehydes and β‐ketoester was studied to develop a regioselective Biginelli‐like reaction. The results indicated that the reaction solvent and the properties of the β‐ketoester component displayed great influence on the regioselectivity. This is the first report about the regioselectivity of the aminotriazole‐based Biginelli‐like reaction. J. Heterocyclic Chem., (2009).

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