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Iodotrimethylsilane-Accelerated One-Pot Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones: A Novel Procedure for the Biginelli-Like Cyclocondensation Reaction at Room Temperature

✍ Scribed by Gowravaram Sabitha; Kusuma B. Reddy; Rangavajjula Srinivas; Jillu S. Yadav

Publisher
John Wiley and Sons
Year
2005
Tongue
German
Weight
61 KB
Volume
88
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A novel Biginelli‐like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me~3~SiI) in MeCN. The reaction proceeds at room temperature by a three‐component one‐pot condensation of ketones with aldehydes and urea to afford 5‐unsubstituted 3,4‐dihydropyrimidin‐2(1__H__)‐ones in good yields (Scheme 1 and Table).

📜 SIMILAR VOLUMES

Iodotrimethylsilane-Accelerated One-Pot
Iodotrimethylsilane-Accelerated One-Pot Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones: A Novel Procedure for the Biginelli-Like Cyclocondensation Reaction at Room Temperature.
✍ Gowravaram Sabitha; Kusuma B. Reddy; Rangavajjula Srivivas; Jillu S. Yadav 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

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