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The first direct coupling of 1-trialkylsilyl-1-alkynes with vinyl triflates; a new access to enynes

โœ Scribed by Ulla Halbes; Philippe Bertus; Patrick Pale

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
61 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

1-Trialkylsilyl-1-alkynes can be directly coupled with vinyl triflates in the presence of TBAF, 3H 2 O and a catalytic amount of AgI and Pd(PPh 3 ) 4 . Functionalized enynes can thus be obtained in good to excellent yields without prior deprotection of the alkyne.

๐Ÿ“œ SIMILAR VOLUMES

A new mild procedure for the direct coup
A new mild procedure for the direct coupling of 1-trimethylsilyl acetylenes with vinyl triflates or aryl iodide
โœ Ulla Halbes; Patrick Pale ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 61 KB

1-Trimethylsilyl acetylenes can be directly coupled with vinyl triflates or aryl iodide in the presence of the appropriate amount of potassium carbonate and methanol and a catalytic amount of AgCl and Pd(PPh 3 ) 4 . Functionalized enynes can thus be obtained in good to excellent yields without prior