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A new mild procedure for the direct coupling of 1-trimethylsilyl acetylenes with vinyl triflates or aryl iodide

✍ Scribed by Ulla Halbes; Patrick Pale

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
61 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

1-Trimethylsilyl acetylenes can be directly coupled with vinyl triflates or aryl iodide in the presence of the appropriate amount of potassium carbonate and methanol and a catalytic amount of AgCl and Pd(PPh 3 ) 4 . Functionalized enynes can thus be obtained in good to excellent yields without prior deprotection of the alkyne.

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