## Abstract (3,4โ^13^C~2~)โLโproline and (^15^N)โLโproline were prepared from the correspondingly labeled Lโglumatic acids via a single scheme in high yield and on a gram scale. The synthetic route is based on the ring closure of Lโglutamic acid to Lโ5โoxoproline and the selective reduction of the
The first chemical conversion of l-proline to l-glutamic acid
โ Scribed by Shigeyuki Yoshifuji; Hideyo Matsumoto; Ken-ichi Tanaka; Yoshihiro Nitta
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 128 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Thermal and charge induced random coil to a-helii transitions of poly-cglutamic acid (PGA) were measured by optical rotatory dispersion in various solvents. The data of PGA in 0.1M NaCl were analyzed by the Zimm-Rice theory. Enthalpy and entropy changes for the coil-to-helix transition in the unioni
## 3804 with NaH provided the pyrrolidone in which the Boc group was cleaved under the reaction conditions. This group was reintroduced with Boc20 to give 7 [87% from 3, oil, [a]D -62.2" (c 1.23, CHCl3)]. Unsaturated 8 was prepared using the reported method. 7 Cyclopropanation of 4 and 8 was carri