The First Catalytic Asymmetric Aza-Henry Reaction of Nitronates with Imines: A Novel Approach to Optically Active β-Nitro-α-Amino Acid- and α,β-Diamino Acid Derivatives
✍ Scribed by Knudsen, Kristian Rahbek; Risgaard, Tine; Nishiwaki, Nagatoshi; Gothelf, Kurt V.; Jørgensen, Karl Anker
- Book ID
- 120604698
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0002-7863
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## Abstract For Abstract see ChemInform Abstract in Full Text.
The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient con
The development of CÀC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v