## Induction of integrin b 1 expression in bone marrow cells after chemotherapy correlates with the overexpression of lung resistance protein and poor outcome in patients with multiple myeloma To the Editor: Acquired drug resistance continues to be one of the major obstacles hindering the successf
The first case of Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia
β Scribed by Jad J. Wakim; Carlos A. Tirado; Jonathan Dowell; Weina Chen
- Book ID
- 116332659
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 459 KB
- Volume
- 205
- Category
- Article
- ISSN
- 2210-7762
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π SIMILAR VOLUMES
Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o
## Abstract ## BACKGROUND Older age is a consistent poor prognostic factor in patients with Philadelphia chromosome (Ph)βpositive chronic myelogenous leukemia (CML). Whether this is related to an intrinsic worse disease biology or to inadequate drug delivery or excessive treatmentβassociated toxic