Philadelphia-negative acute myeloid leukemia with new chromosomal abnormalities developing after first-line imatinib treatment for chronic phase chronic myeloid leukemia

✍ Scribed by Carmen Fava; Jorge Cortes

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 306 KB
• Volume: 83
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.21230

✦ Synopsis

Induction of integrin b 1 expression in bone marrow cells after chemotherapy correlates with the overexpression of lung resistance protein and poor outcome in patients with multiple myeloma

To the Editor: Acquired drug resistance continues to be one of the major obstacles hindering the successful treatment of multiple myeloma (MM). Expression of one or several multidrug resistance (MDR) genes such as lung resistance protein (LRP) and MDR1 is associated with resistance to