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The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

✍ Scribed by Gianna Elena Hammer; Takayuki Kanaseki; Nilabh Shastri


Book ID
116570741
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
477 KB
Volume
26
Category
Article
ISSN
1074-7613

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DM and DO shape the repertoire of peptid
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The presentation of antigenic peptides by MHC class II molecules is essential for activation of CD4+ T cells. The formation of most peptide-MHC-class-II complexes is influenced by the actions of two specialized accessory proteins--DM and DO--located in the endosomal/lysosomal system where peptide lo