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The Ferrous Heme of Soluble Guanylate Cyclase: Formation of Hexacoordinate Complexes with Carbon Monoxide and Nitrosomethane

✍ Scribed by Stone, James R.; Marletta, Michael A.

Book ID: 127309873
Publisher: American Chemical Society
Year: 1995
Tongue: English
Weight: 815 KB
Volume: 34
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi00050a021

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## Background: Nitric oxide (.no) is used in biology as both an intercellular signaling agent and a cytotoxic agent. in signaling, submicromolar quantities of .no stimulate the soluble isoform of guanylate cyclase (sgc) in the receptor cell. .no increases the vmax of this heterodimeric hemoprotein