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The fate of desmosomes in trypsinized tissue

โœ Scribed by Overton, Jane

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
840 KB
Volume
168
Category
Article
ISSN
0022-104X

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โœฆ Synopsis

Embryonic animal epithelial tissue in which desmosomes are well developed has been dispersed by trypsinization and the behavior of desmosomal halves observed. An earlier report left open the question of whether desmosomes were broken down or reincorporated into the reorganized tissue. A more detailed study shows that dispersed cells, or cells which are partially separated, phagocytize half desmosomes left at the cell surface. The resulting vacuoles are angular during early stages of the process indicating that desmosomes are relatively rigid. They later become spherical and characteristic desmosnmal morphology disappears. These results are discussed in connection with morphology in genetic disturbances and in development.

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