The expression of tumor-rejection antigen “Mage” genes in pancreatic carcinoma
✍ Scribed by Simon, B.; Prasnika, N.; Arnold, R.
- Book ID
- 123338101
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 168 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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The human genes MAGE-I and -3 encode melanoma peptide antigens that are recognized by autologous cytotoxic T lymphocytes. Tumors expressing MAGE genes are potential targets for cancer immunotherapy, because MAGE genes are expressed only in tumor tissue and not in any normal tissue except testis and
## Abstract ## BACKGROUND The authors recently reported that the SART2 and SART3 antigens encode tumor epitopes recognized by HLA‐A24‐restricted and tumor‐specific cytotoxic T lymphocytes (CTLs) established from esophageal carcinoma patients. The current study investigated these antigens to explor