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The expression of the pro-apoptotic gene Air is inducible in human pancreatic adenocarcinoma cells

✍ Scribed by Morena d'Avenia; Alessandra Rosati; Maria Antonietta Belisario; Mario Torino; Gaetano Torino; Maria Caterina Turco; Maria Pascale

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
549 KB
Volume
226
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

We previously identified __a__poptosis‐__i__nduced __r__egulator (air) as a pro‐apoptotic transcript whose expression was repressed by NF‐κB/Rel activity in the human leukemia cell line Jurkat (Turco, Lamberti, Bisogni, Romano, Petrella, Ammirante, Rosati, d'Avenia, Arra, Spugnini, Venuta, 2007, Leukemia 21:2557–2559). In this paper, we report that air sequence is detectable by Southern blot in human healthy donors (HHD) leukocytes and in two pancreatic adenocarcinoma cell lines (AsPC‐1 and PANC‐1), providing the first definitive evidence of air gene presence in human genome. In addition, we demonstrate that air expression is induced in the tumor cell lines by a naturally occurring ROS‐inducing compound, phenethyl isothiocyanate (PEITC), a potential dietary cancer chemopreventive agent. Since PEITC inhibits NF‐κB activation, air induction by this agent is consistent with the suppressive effect of NF‐κB on air expression. This finding contributes a new clue to the role of NF‐κB in regulating oxidative stress‐induced pro‐apoptotic genes and identifies a novel potential tool for enhancing pancreas cancer response to treatment. J. Cell. Physiol. 226: 2207–2212, 2011. © 2011 Wiley‐Liss, Inc.

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