## Abstract Human T cells require two discrete signals to initiate their proliferation. In Jurkat T cells the first signal can be provided by the phorbol ester TPA and the second by the calcium ionophore A23187. We have isolated a cDNA from Jurkat T cells representing mRNA induced by TPA but inhibi
Calcium ionophore-induced apoptosis of human B cells is preceded by the induced expression of early response genes
✍ Scribed by Zhi-Qiang Ning; John J. Murphy
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 510 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Presenilins (PSs) are mutated in a majority of familial Alzheimer disease (FAD) cases. Mutated PSs may cause FAD by a number of pro‐apoptotic mechanisms, or by regulating γ‐secretase activity, a protease involved in β‐amyloid precursor protein processing to the neurotoxic β‐amyloid pept
## Abstract We previously identified __a__poptosis‐__i__nduced __r__egulator (__air__) as a pro‐apoptotic transcript whose expression was repressed by NF‐κB/Rel activity in the human leukemia cell line Jurkat (Turco, Lamberti, Bisogni, Romano, Petrella, Ammirante, Rosati, d'Avenia, Arra, Spugnini,
## Abstract Breast cancer remains the major cause of cancer‐related deaths in women world‐wide. The heterogeneity of breast cancer has further complicated the progress of target‐based therapies. Triple negative breast cancers, lacking estrogen receptor, progesterone receptor and the Her‐2/neu (ErbB
The degradation products of hyaluronan are known to stimulate endothelial-cell proliferation and to promote neovascularization associated with angiogenesis, whilst native high-molecular-weight hyaluronan is inhibitory to these processes. To investigate the cellular signalling pathways coupled to hya