The Expression of the F-Box Protein Skp2 is Negatively Associated with p27 Expression in Human Pituitary Tumors
✍ Scribed by Madalina Musat; Márta Korbonits; Megan Pyle; Maria Gueorguiev; Blerina Kola; Damian G. Morris; Michael Powell; Constantin Dumitrache; Catalina Poiana; Ashley B. Grossman
- Book ID
- 111549577
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 625 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1386-341X
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## Abstract The F‐box protein Skp2 positively regulates the G1‐S transition by promoting degradation of the cyclin‐dependent kinase inhibitor p27^kip1^ (p27). Recent evidence has suggested an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed imm