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Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2

✍ Scribed by Mechthild Wagner; Barbara Hampel; Evelyne Hütter; Gerald Pfister; Wilhelm Krek; Werner Zwerschke; Pidder Jansen-Dürr


Book ID
114253649
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
383 KB
Volume
37
Category
Article
ISSN
0531-5565

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## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit