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The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas

✍ Scribed by Zhenye, Li; Chuzhong, Li; Youtu, Wu; Xiaolei, Lan; Lei, Cao; Lichuan, Hong; Hongyun, Wang; Yonggang, Wu; Fei, Wang; Yazhuo, Zhang

Book ID
125401202
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
463 KB
Volume
12
Category
Article
ISSN
1479-5876

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## Abstract Bleomycin produces its fibrogenic effect, at least in part, by TGF‐β1 secretion. Treatment of IMR‐90 human embryonic lung fibroblasts with bleomycin at 0.5 μg/ml results in a 1.6‐fold increase of TGF‐β1 as determined by a specific ELISA assay for TGF‐β1 after acidification of the condit