The expression of functional human parathyroid hormone in a gene therapy model for osteoporosis
β Scribed by Bainan Liu; Jianguo Tang; Jianguo Ji; Jun Gu
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 205 KB
- Volume
- 317
- Category
- Article
- ISSN
- 0302-766X
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We have previously reported that alkaline phosphatase (ALPase) is functionally involved in calcium uptake by several osteoblast-like cell lines. We have extended these studies to investigate the actions of ALPase on the CAMP response to and the receptor binding of human parathyroid hormone (hPTH) an
## Abstract ## Background A model for __in vivo__ gene therapy based on electroporation of human growth hormone (hGH)βcoding naked DNA in the muscle of dwarf (lit/lit) and immunodeficient dwarf (lit/scid) mice is described. ## Methods A plasmid containing the ubiquitin C promoter and the genomic