✦ LIBER ✦

The experimental administration of lead to rats in neuropathological and behavioural studies

✍ Scribed by Christopher Winder; Neil G. Carmichael

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 930 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050304

No coin nor oath required. For personal study only.

✦ Synopsis

The experimental investigation of the effects of lead have been studied for nearly 20 years. In that time, a variety of neurobiological processes have been reported to be altered following ingestion of lead. Most routes of administration and a bewildering number of doses have been employed to administer lead to experimental animals. However, inadequate characterization of dose regimes has impaired understanding of any effects, and their correlation to conditions of human exposure. As an index of lead burden, blood lead remains the most reliable means of assessing recent lead absorption. It is clear that a large number of model systems and dosing regimes do not address the problems of human clinical or subclinical lead intoxication. It is also clear from brain lead measurements in experimental animals that lead is selectively sequestered into specific areas of the control nervous system.

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