Towards a rational approach to the treatment of peritonitis: An experimental study in rats

✍ Scribed by D. J. McAvinchey; P. T. McCollum; Mr G. Lynch

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 506 KB
• Volume: 71
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800710925

✦ Synopsis

Peritoneal infection progresses through defined stages: contamination, injlammation and abscess formation. An experimental model of established peritonitis without adjuvant in the rat was used to test the efect of various local and systemic agents on survival. There was significant improvement in all treatment groups except those treated with antiseptic lavage using PVP-I and noxythiolin. Intramuscular ampicillin improved survival from 40 to 60 per cent while intramuscular amikacin combined with local irrigation with metronidazole reduced mortality to nil (P < 0.001). Both cephradine and metronidazole used as peritoneal lavage solutions improved survival ( P <0.005) when compared with the controls but the diflerence was not significant when compared with irrigation with Hartmann's solution. Metronidazole given rectally also improved survival from 40 to 60 per cent but this diflerence was not significant. We conclude that survival in established peritonitis depends upon adequate antibiotic therapy.