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The evolutionary transition from uracil to thymine balances the genetic code

✍ Scribed by Jörgen Jonsson; Maria Sandberg; Svante Wold

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
539 KB
Volume
10
Category
Article
ISSN
0886-9383

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✦ Synopsis

A multivariate quantitative physicochemical characterization of the five bases adenine (A), cytosine (C), guanine (G), thymine (T) and uracil (U), followed by principal component analysis, shows that the relative dissimilarities between the bases of DNA (A, C, G and T) are almost the same (i.e. balanced). In contrast, mRNA (containing U instead of T) has a considerably larger relative physicochemical similarity between C and U than between all other pairs of bases and is therefore inherently more unbalanced. These results provide a physicochemical explanation of the presence of thymine instead of uracil as an element of DNA. The principal component scores enable a quantitative description of nucleic acid sequence data to be made for structure-activity modelling purposes.

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