✦ LIBER ✦

The evolution of protein interaction networks in regulatory proteins

✍ Scribed by Gregory D. Amoutzias; David L. Robertson; Erich Bornberg-Bauer

Publisher: Hindawi Publishing Corporation
Year: 2004
Tongue: English
Weight: 100 KB
Volume: 5
Category: Article
ISSN: 1531-6912
DOI: 10.1002/cfg.365

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✦ Synopsis

Interactions between proteins are essential for intracellular communication. They form complex networks which have become an important source for functional analysis of proteins. Combining phylogenies with network analysis, we investigate the evolutionary history of interaction networks from the bHLH, NR and bZIP transcription-factor families. The bHLH and NR networks show a hub-like structure with varying γ values. Mutation and gene duplication play an important role in adding and removing interactions. We conclude that in several of the protein families that we have studied, networks have primarily arisen by the development of heterodimerizing transcription factors, from an ancestral gene which interacts with any of the newly emerging proteins but also homodimerizes.

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