We have developed an experimental approach to map the complete binding surface of any crystalline macromolecule that is fast and flexible. Crystals of the target protein are transferred into organic solvents and the crystal structures are determined at high (about 2Å) resolution. The sites where the
Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction
✍ Scribed by David Margulies; Yarden Opatowsky; Steven Fletcher; Ishu Saraogi; Lun K. Tsou; Sourav Saha; Irit Lax; Joseph Schlessinger; Andrew D. Hamilton
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 396 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1439-4227
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Hundreds of extracellular stimuli are received by cells via the pathways consisting of three basic components: cell-surface receptors, heterotrimeric G proteins, and intracellular effector enzymes or ion channels. A number of additional molecules, including G protein-coupled receptor kinases (GRKs),