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The Evolution of Catalytic Efficiency and Substrate Promiscuity in Human Theta Class 1-1 Glutathione Transferase

✍ Scribed by Karl E. Griswold; Nandini S. Aiyappan; Brent L. Iverson; George Georgiou


Book ID
116663280
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
441 KB
Volume
364
Category
Article
ISSN
0022-2836

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A manual threading approach is used to model the human glutathione transferase T1-1 based on the coordinates of the related Theta class enzyme T2-2. The low level of sequence identity (about 20%), found in the C-terminal extension in conjunction with a relative deletion of about five residues makes