✦ LIBER ✦

The evaluation of solution- and solid-phase approaches to the divergent synthesis cinnoline and phenanthrene ring systems

✍ Scribed by Chinh T. Bui; Bernard L. Flynn

Book ID: 106468372
Publisher: Springer
Year: 2010
Tongue: English
Weight: 275 KB
Volume: 15
Category: Article
ISSN: 1381-1991
DOI: 10.1007/s11030-010-9235-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Convergent solid-phase and solution appr

Convergent solid-phase and solution approaches in the synthesis of the cysteine-rich Mdm2 RING finger domain

✍ Zoe Vasileiou; Kostas Barlos; Dimitrios Gatos 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

## Abstract The RING finger domain of the Mdm2, located at the __C__‐terminus of the protein, is necessary for regulation of p53, a tumor suppressor protein. The 48‐residues long Mdm2 peptide is an important target for studying its interaction with small anticancer drug candidates. For the chemical

Evaluation of Solution and Solid-Phase A

Evaluation of Solution and Solid-Phase Approaches to the Synthesis of Libraries of α,α-Disubstituted-α-acylaminoketones

✍ Garcia, Javier; Mata, Ernesto G.; Tice, Colin M.; Hormann, Robert E.; Nicolas, E 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 486 KB

Solid-Phase Convergent Approaches to the

Solid-Phase Convergent Approaches to the Synthesis of Native Peptides and Proteins

✍ Paul Lloyd-Williams; Ernest Giralt 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB

Solid and solution phase synthesis of α-

Solid and solution phase synthesis of α-keto amides via azetidinone ring-opening: Application to the synthesis of poststatin

✍ Seock-Kyu Khim; John M. Nuss 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 276 KB

3,3-Diethoxy-N-sulfonyl and carbamoyl azetidin-2-ones undergo efficient ring-opening reaction with various amine nucleophiles. Subsequent acid hydrolysis of the ketal moiety generated 0t-keto amides in excellent overall yields. The naturally occurring serine protease inhibitor poststatin was synthes

Combined solid-phase and solution approa

Combined solid-phase and solution approach for the synthesis of large peptides or proteins

✍ Yuji Nishiuchi; Hideki Nishio; Tatsuya Inui; József Bódi; Terutoshi Kimura 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

In the synthesis of large peptides or proteins, highly homogeneous segments are indispensable for a convergent strategy either on a solid-phase resin or in solution. Employing Boc/Bzl chemistry to prepare fully protected segments with a free h-carboxyl group from the solid support, base-labile linke

ChemInform Abstract: Solid and Solution

ChemInform Abstract: Solid and Solution Phase Synthesis of α-Keto Amides via Azetidinone Ring-Opening: Application to the Synthesis of Poststatin.

✍ Seock-Kyu Khim; John M. Nuss 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views