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The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat

✍ Scribed by R. J. Barrett; J. H. Harleman; E. C. Joseph

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 444 KB
Volume: 8
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550080402

No coin nor oath required. For personal study only.

✦ Synopsis

The total LDH, HBDH and LDH isoenzyme activities were assessed in a number of rat tissues. HBDH did not correlate with LD1 and LD2 isoenzyme activity in tissues with high HBDH activity. HBDH therefore cannot be used as a marker for cardiac necrosis in the rat. In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD1 isoenzymes showed any significant change but only within the first 24 h of treatment. No statistically significant differences were seen in the plasma AST, CK, CK-MB and total LDH activities.

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