The evaluation of biological interactions using response surface methodology

✍ Scribed by Richard P. Solana; Vernon M. Chinchilli; Walter H. Carter; John D. Wilson; Richard A. Carchman

• Book ID: 104627654
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 798 KB
• Volume: 3
• Category: Article
• ISSN: 0742-2091
• DOI: 10.1007/bf00117864

✦ Synopsis

Solana, Chinchilli, Carter, Wilson and

Carchman what level of effect was compared)more potent than bischloroethylnitrosourea. For the cis-diamminedichloroplatinum (II)/ bis-chloroethylnitrosourea combinations, an increasingly lessthan-additive interaction was detected. The analysis of these combinations demonstrates the strength of response surface methodology, a collection of mathematical and statistical techniques for detecting, analyzing and describing the biological effects resulting from exposures to multiple cytotoxic agents. The descriptive ability of these procedures is shown to be useful in that it leads to the suggestion of hypotheses regarding mechanisms of action.