The Eukaryotic Replisome: a Guide to Protein Structure and Function

✍ Scribed by Stuart MacNeill (auth.), Stuart MacNeill (eds.)

Publisher: Springer Netherlands
Year: 2012
Tongue: English
Leaves: 343
Series: Subcellular Biochemistry 62
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

✦ Table of Contents

Front Matter....Pages i-viii
Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview....Pages 1-17
Evolutionary Diversification of Eukaryotic DNA Replication Machinery....Pages 19-35
The Origin Recognition Complex: A Biochemical and Structural View....Pages 37-58
Archaeal Orc1/Cdc6 Proteins....Pages 59-69
Cdt1 and Geminin in DNA Replication Initiation....Pages 71-87
MCM Structure and Mechanics: What We Have Learned from Archaeal MCM....Pages 89-111
The Eukaryotic Mcm2-7 Replicative Helicase....Pages 113-134
The GINS Complex: Structure and Function....Pages 135-156
The Pol α-Primase Complex....Pages 157-169
The Structure and Function of Replication Protein A in DNA Replication....Pages 171-196
Structural Biology of Replication Initiation Factor Mcm10....Pages 197-216
Structure and Function of Eukaryotic DNA Polymerase δ....Pages 217-236
DNA Polymerase ε....Pages 237-257
The RFC Clamp Loader: Structure and Function....Pages 259-279
PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA....Pages 281-299
The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation....Pages 301-326
DNA Ligase I, the Replicative DNA Ligase....Pages 327-341
Back Matter....Pages 343-345

✦ Subjects

Biomedicine general; Biochemistry, general; Protein Science; Protein Structure; Nucleic Acid Chemistry; Cancer Research

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