The ethanol metabolite acetaldehyde inhibits the induction of long-term potentiation in the rat dentate gyrus in vivo
โ Scribed by Kazuho Abe; Shinichi Yamaguchi; Minoru Sugiura; Hiroshi Saito
- Book ID
- 110004482
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 172 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0007-1188
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The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1)
## Abstract In this study, we investigated whether the expression of pyridoxal kinase (PLK) and pyridoxineโ5โฒโphosphate oxidase (PNPO) are altered following longโterm potentiation (LTP) induction, and whether TatโPLK and TatโPNPO transductions affect LTP induction and pairedโpulse responses in the
## Abstract The dentate gyrus (DG) is a region of the hippocampus intimately involved with learning and memory. Prenatal exposure to either stress or ethanol can reduce longโterm potentiation (LTP) in the male hippocampus but there is little information on how these prenatal events affect LTP in th