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The estimation of sibling genetic risk parameters revisited

✍ Scribed by Guohua Zou; Hongyu Zhao

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
107 KB
Volume
26
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

This report points out that some sibling genetic risk parameters can be regarded as the ratios of the characteristic values in the ascertainment subpopulation. Based on this observation, we reconsider Olson and Cordell's ([2000] Genet. Epidemiol. 18:217–235) and Cordell and Olson's ([2000] Genet. Epidemiol. 18:307–321) estimators, and re‐derive these estimators. Furthermore, we provide the closed‐form variance estimators. Simulation results suggest that our proposed estimators perform very well, and single ascertainment may be better than complete ascertainment for estimating these genetic parameters. Β© 2004 Wiley‐Liss, Inc.

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