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Maximum Likelihood Estimation of Genetic Parameters in Cell Populations

✍ Scribed by Dr. W. Y. Tan; Conrad Tou

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
524 KB
Volume
29
Category
Article
ISSN
0323-3847

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✦ Synopsis

I n this paper we consider a cell population such 88 bacteria consisting of two t y p of cells, mutant and nonmutant. Under the mutation and homogeneous pure birth promme%, this paper derives a maximum likelihood estimation procedure for estimating mutation rate and birth rate. The method is applied to Newcombe's data; further some Monte Carlo studies are generated. The numerical reeulta indicate that the method is quite efficient for estimating genetic parametera in Cell pOpUlIbtiOIl8.

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