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The ERK and PI3K signaling pathways mediate inhibition of insulin-like growth factor-1 receptor mRNA expression by somatostatin

✍ Scribed by Andrea Hanson; Deepak Poudyal; Alison Hagemeister; Katie M. Reindl; Mark A. Sheridan


Book ID
116734676
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
644 KB
Volume
315
Category
Article
ISSN
0303-7207

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✍ Atsumi Nitta; Wen-Hua Zheng; RΓ©mi Quirion πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 190 KB

## Abstract Corticosterone (CORT) is well known to induce neuronal damage in various brain regions including the hippocampus, but the precise mechanism(s) of action underlying these effects has yet to be fully established. Insulin‐like growth factor‐1 (IGF‐1) is a trophic factor promoting cell surv