## Epstein -Barr Virus (EBV) is implicated in the pathogenesis of endemic Burkitt's lymphoma (BL), B-cell lymphomas occuring under immunosuppression, nasopharyngeal carcinoma and Hodgkin's disease. Two distinct patterns of latent EBV gene expression occur in EBV-associated lymphomas. BLS typically
The epstein-barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in burkitt lymphoma lines
โ Scribed by Hiroshi Nakagomi; Riccardo Dolcetti; Maria Teresa Bejarano; Pavel Pisa; Rolf Kiessling; Maria G. Masucci
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 733 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0020-7136
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## Abstract To assess the role of the EpsteinโBarr virus (EBV) latent membrane protein 1 (LMP1) gene in the development of Hodgkin's lymphoma (HL), the polymorphism of this gene in EBV isolates from different geographic locations was analyzed. A 497 bp fragment spanning LMP1 gene exons 1 and 2 was
## Abstract There are two types of Epstein Barr virus (EBV): EBVโ1 and EBVโ2, distinguished by genomic polymorphism in the genes encoding the nuclear antigens (EBNAโ2, โ3A, โ3B, โ3C). Latent membrane protein 1 (LMPโ1) is an EBV protein with known oncogenic properties. Different variants had been de
Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gen