𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of CD44 expression by the epstein-barr virus latent membrane protein LMP1 is associated with lymphoma dissemination

✍ Scribed by Jürgen Walter; Volker Schirrmacher; Donald Mosier

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
976 KB
Volume
61
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Epstein

-Barr Virus (EBV) is implicated in the pathogenesis of endemic Burkitt's lymphoma (BL), B-cell lymphomas occuring under immunosuppression, nasopharyngeal carcinoma and Hodgkin's disease. Two distinct patterns of latent EBV gene expression occur in EBV-associated lymphomas. BLS typically display expression of the nuclear antigen EBNAI only, whereas EBV-associated, non-Burkitt B-cell lymphomas express at least 9 latent viral genes (6 EBNAs and 3 latent membrane proteins), reminiscent of in vitro EBV-immortalized lymphoblastoid cell lines (LCL). BLs are characterized by local, extra-nodal growth, whereas EBV-associated B-cell lymphomas often disseminate to peripheral lymphoid tissue. We show here that BL cells forming local tumors after xenotransplantation into SCID mice disseminate to lymphoid tissue following introduction of the latent membrane protein I (LMPI) gene. Introduction of LMPl into BL cells induced expression of CD44 on the cell surface, a molecule implicated in enhanced lymphoid tumor growth and MATERIAL AND METHODS

Cell lines and lymphoma growth

The BL cell lines and the corresponding autologous lymphoblastoid cells (LCL) [BL37 (myc translocation: 8/22), LCL 176; BL64 (8/2), LCL 549; BL54 (8/14), LCL 470; BL60

📜 SIMILAR VOLUMES

Isolation and analysis of two strongly t
Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma
✍ Anja M. Mehl; Nicole Fischer; Martin Rowe; Frank Hartmann; Heiner Daus; Lorenz T 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 154 KB 👁 2 views

Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gen

Clonality analysis by sequence variation
Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein–Barr virus infection
✍ Yukiko Shibata; Yo Hoshino; Shinya Hara; Hiroshi Yagasaki; Seiji Kojima; Yukihir 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB 👁 1 views

## Abstract Chronic active Epstein–Barr virus (EBV) infection is a severe systemic disease associated with high rates of mortality and morbidity. Recent studies suggest that the clonal expansion of EBV‐infected T or natural killer cells plays a crucial role in the pathogenesis of chronic active EBV