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The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family

✍ Scribed by Heath-Engel, H M; Chang, N C; Shore, G C


Book ID
109970634
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
333 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Bcl‐2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of pro‐ versus antiapoptotic Bcl‐2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptiona