✦ LIBER ✦

The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics

✍ Scribed by Hauck, R.-S.; Elmazar, M.M.A.; Plum, C.; Nau, H.

Book ID: 123569294
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 501 KB
Volume: 60
Category: Article
ISSN: 0378-4274
DOI: 10.1016/0378-4274(92)90269-P

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The Enantiomers of the Valproic Acid Ana

The Enantiomers of the Valproic Acid Analogue 2-n-Propyl-4-pentynoic Acid (4-yn-VPA): Asymmetric Synthesis and Highly Stereoselective Teratogenicity in Mice

✍ Ralf-Siegbert Hauck; Heinz Nau 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 984 KB

Stereoselective dysmorphogenicity of the

Stereoselective dysmorphogenicity of the enantiomers of the valproic acid analogue 2-N-propyl-4-pentynoic acid (4-yn-VPA): Cross-species evaluation in whole embryo culture

✍ Andrews, James E.; Ebron-McCoy, Marian T.; Bojic, Ursula; Nau, Heinz; Kavlock, R 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 55 KB

We previously reported the in vitro differential stereoselective dysmorphogenic potential of the R(+) and S(-) enantiomers of 2n-propyl-4-pentynoic acid (4-yn-VPA) in mice. To determine whether this stereoselectivity is species specific, we evaluated the dysmorphogenic potential of these isomers as