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The Enantiomers of the Valproic Acid Analogue 2-n-Propyl-4-pentynoic Acid (4-yn-VPA): Asymmetric Synthesis and Highly Stereoselective Teratogenicity in Mice

โœ Scribed by Ralf-Siegbert Hauck; Heinz Nau


Book ID
110341608
Publisher
Springer US
Year
1992
Tongue
English
Weight
984 KB
Volume
09
Category
Article
ISSN
0724-8741

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Stereoselective dysmorphogenicity of the
โœ Andrews, James E.; Ebron-McCoy, Marian T.; Bojic, Ursula; Nau, Heinz; Kavlock, R ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 55 KB

We previously reported the in vitro differential stereoselective dysmorphogenic potential of the R(+) and S(-) enantiomers of 2n-propyl-4-pentynoic acid (4-yn-VPA) in mice. To determine whether this stereoselectivity is species specific, we evaluated the dysmorphogenic potential of these isomers as